Research Activities

CTMRF Funded Research Projects during the period 2018- 2019.

Determination Of Pneumonia Etiology, Association Between Nasopharyngeal Load Of S.pneumoniae, Viral Coinfection And Clinical Severity Of Pneumonia Among Children < 5 Years At KKCTH, Chennai.

Principal Investigator: Dr. Anand Manoharan, Director (Research), CTMRF

Year of sanction: 2018

Developing a rapid diagnostic platform to detect antibodies to Salmonella typhi using a synthetic & unique Salmonella specific outer membrane antigen fragment

Principal Investigator: Dr. Anand Manoharan, Director (Research), CTMRF

Year of sanction: 2018

Determination of trend in third generation cephalosporin MIC of Salmonella isolated in blood

Principal Investigator: Dr. P. Sulochana Putli Bai, Laboratory Director & Head of Microbiology, KKCTH

Year of sanction: 2018

Assessment of nutritional status in children with cancer

Principal Investigator: Dr. Arathi Srinivasan, Associate Consultant, Haemato-Oncology, KKCTH

Year of sanction: 2018

Study of genetic polymorphisms in methotrexate metabolism to predict methotrexate toxicity in children with cancer

Principal Investigator: Dr. Julius Xavier Scott, Visiting Consultant, Haemato-Oncology, KKCTH

Year of sanction: 2018

Frequency and clinical outcomes of Respiratory Viral Infections in children with cancer presenting with febrile neutropenia

Principal Investigator: Dr. S. Balasubramanian, Medical Director and Head of the Dept. of Pediatrics, KKCTH

Year of sanction: 2018

CTMRF Research Laboratory

Year of sanction: 2018

Correlation of serum lactate levels, Perfusion index and Pleth variability index with invasive BP in late preterm and term infants with shock in level III NICU: a prospective observational study

Dr. Chandrakumar N, MD, DM (Neonatology), HOD-Neonatology, KKCTH

Year of sanction: 2019

Comparative evaluation of the diagnositc accuracy of dengu NSI ELISA, IgM, PCR and a newly designed LAMP (loop mediated amplification test): A study from a pediatric teaching hospital in Chennai

Principal Investigator: Dr. S. Balasubramanian, Medical Director and Head of the Dept. of Pediatrics, KKCTH

Year of sanction: 2019

Ongoing Research Proposal

A Phase 4, Randomized, Open-Label Trial to describe the Safety, Tolerability, and Immunogenicity of 13-Valent Pneumococcal Conjugate Vaccine formulated in Multidose Vials when given with routine Pediatric Vaccines in healthy infants in India”

Principal Investigator: Dr. S. Balasubramanian, Medical Director and Head of the Dept. of Pediatrics, KKCTH

Funding Agency: Pfizer

Duration: 2018-20

A Phase 4, Open-Label, Single Arm, Multicenter Study to describe the Safety of 13-Valent Pneumococcal Conjugate Vaccine in children 6 to 17 years of age in India.

Principal Investigator: Dr. S. Balasubramanian, Medical Director and Head of the Dept. of Pediatrics, KKCTH

Funding Agency: Pfizer

Duration: 2018-19

A Multicentric,Randomized,Double Blind,Placebo controlled Trial to assess the Efficacy and safety of Saccharomyces Boulardii CNCM-I 3799 Bacillus Subtillis CU-1 combination For treatment of Acute Diarrhoea in Indian children

Principal Investigator: Dr. S. Balasubramanian, Medical Director and Head of the Dept. of Pediatrics, KKCTH

Funding Agency: Medclin Research Pvt Ltd-Kolkata

Duration: 2018-19

Hospital based surveillance to assess the distribution and replacement of serotypes of Streptococcus pneumoniae in the nasopharyngeal swab isolates in children aged 1 month to 59 months presenting with fever, and pneumonia attending select hospital-based sentinel sites across India after the introduction of the Pneumococcal Conjugate Vaccine in the Universal Immunization Programme in India.

Principal Investigator: Dr. S. Balasubramanian, Medical Director and Head of the Dept. of Pediatrics, KKCTH/p>

Funding Agency: ICMR-National Institute of Epidemiology

Duration: 2011-2019

Impact Assessment Study of Rotavirus Vaccine and Intussusception surveillance’

Principal Investigator: Dr. S. Balasubramanian, Medical Director and Head of the Dept. of Pediatrics, KKCTH

Funding Agency: Welcome Trust Research Laboratory, CMC Vellore /Indian Council for Medical Research (ICMR)

Duration: 2017-2021

National Surveillance for Enteric Fever

Principal Investigator: Dr. P. Sulochana Putli Bai, Laboratory Director & Head of Microbiology, KKCTH

Funding Agency: Welcome Trust Research Laboratory, CMC Vellore

Duration: 4 years - initiated on September 2017

Highlights on ongoing research projects at CTMRF

Impact Assessment Study of Rotavirus Vaccine and Intussusception surveillance:
In collaboration with CMC, Vellore.
As on 31st  Jul 2019, 681 cases  enrolled of which 201 were rotavirus positive & 85 intussusception cases were enrolled of which 2 samples were rotavirus positive.
Pneumonia surveillance:
Project in collaboration with National Institute of Epidemiology, Chennai.
As on 31st Jul 2019, 208 suspected pneumonia cases were enrolled and out of which 6 were culture positive S.pneumoniae .
National Surveillance for Enteric Fever (Surveillance System of Enteric Fever in India):
10751 blood cultures done in a two-year time period.  Of these, 153 Salmonella typhi and 34 S.paratyphi strains were isolated.  Totally 157 subjects enrolled in the study.
Two scientific papers were presented at the 11th International Conference on Typhoid and other Invasive Salmonellosis at Hanoi, Vietnam by study team.
Frequency and clinical outcomes of Respiratory Viral Infections in children with cancer presenting with febrile neutropenia
15 children included in this study since study inception (January 2019), 13 subjects below 5 years
Rhinovirus most common followed by coronavirus 43.
Comparative evaluation of the diagnositc accuracy of dengue NSI ELISA, IgM, PCR and a newly designed LAMP (loop mediated amplification test): A study from a pediatric teaching hospital in Chennai
Since May 2019, 51 children clinically suspected with Dengue included, 32 (62.7%) positive by real time PCR for dengue.
Dengue serotype 2 most common (48%) followed by type 1 and 3 ( 22% each).
Study collaborates with IITM Research Park for development of LAMP Test.
Retrospective chart review of children treated with tuberculosis-
Project in collaboration with REACH, Chennai.
Developing a rapid diagnostic platform to detect antibodies to Salmonella typhi using a synthetic & unique Salmonella specific outer membrane antigen fragment

Project in collaboration with Center for Bioseparation Technology, Vellore Institute of Technology, Vellore

 

KKCTH chosen as the nodal center for the National Registry on Rare and Other Disorders by the Indian Council for Medical Research

Comments are closed.